Sanctifying Elixir Usage Guide: Best Sets to Transmute in 2026

Introduction: The Value of Sanctifying Elixir in 2026

Resin efficiency is the most critical metric for endgame progression. Version 5.0 introduced the Sanctifying Elixir system, revolutionizing artifact progression by allowing players to target specific main stats and substats. This mitigates the heavy RNG reliance of domain farming. The Artifact Transmuter, found in the Adventurer's Handbook Embattle tab (Chapter 4), is the central hub for this system.

Consuming Sanctifying Elixirs crafts 5-star artifacts essential for keeping up with power creep in Natlan and Snezhnaya. To maximize your account's potential or afford resin refills, consider a buy Genesis Crystals strategy through buffget.

As Version 6.0 approaches in September 2025, demand for high-quality artifacts will rise. You must strategically allocate limited Elixirs toward high-ROI sets like the Natlan-exclusive Obsidian Codex, rather than wasting them on easier-to-farm or outdated gear.

How Sanctifying Elixir Transmutation Works

The Artifact Transmuter converts raw materials into targeted 5-star equipment. You select the set, piece (Flower, Plume, Sands, Goblet, Circlet), main stat, and two initial substats. This ensures the artifact is viable immediately, unlike random domain drops.

RNG still affects the final two substats. However, a Version 5.5 update (August 28, 2025) guarantees two substat upgrades when leveling a crafted artifact to +20, locking them in. This mechanic drastically increases the value of crafted artifacts by ensuring a minimum power floor.

Transmutation Costs (by Piece):

• Flower of Life / Plume of Death: 1 Elixi

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• Sands of Eon: 2 Elixirs (S1, S3, S4, S5) or 4 Elixirs (S2)
• Goblet of Eonothem: 4 Elixirs
• Circlet of Logos: 3 Elixirs (S1, S3, S4, S5) or 4 Elixirs (S2)

Maximizing Sanctifying Elixir Acquisition

Efficient gathering requires combining one-time exploration rewards and recurring gameplay loops.

Artifact Extraction

The primary source is Artifact Extraction, converting unwanted 5-star artifacts into Progress points. This is limited to once per version cycle. You need 100 Progress points for 1 Sanctifying Elixir.

To maximize yield, feed unequipped 5-star artifacts that are at least +4 into the Transmuter:

• +4: 4 Progress points
• +12: 14 Progress points
• +16: 22 Progress points
• +20: 30 Progress points (S4) or 20 points (S1)

Exploration & Events

• Natlan Tribal Secret Spaces: 6 total (1 Elixir each). Unlock by offering specific Obsidian Rings (Yellow, Green, Azure, Crimson, Sunset-Blue) crafted from fragments found in chests.
• Tablet of Tona: Levels 10, 20, 30, and 40 grant 1 Elixir each (Level 50 reportedly available in S3).
• Gnostic Hymn Battle Pass: Level 26 rewards 1 Elixir.
• Imaginarium Theater: Earn 1 Elixir each for reaching 9 and 12 Stellas once per season.
• Nod-Krai Meeting Points: Construction Level 5 rewards 3 Elixirs.

Strategic Crafting for the 2026 Meta

Prioritizing sets is the most important decision you can make. With a limit of 1 craft per set per version (S4, S5) or 2 pieces (S3), resources are tight. Prioritize expensive pieces like Goblets (4 Elixirs) and Circlets (3 Elixirs) for sets that are difficult to farm or have high stat requirements.

For the 2026 meta, focus on Natlan sets like Obsidian Codex. Crafting these allows you to bypass domain RNG, specifically for Elemental Mastery or Crit Rate main stat Goblets which are notoriously hard to acquire. If you need to expedite progress, use a Genshin Impact top up via buffget.

Pro Tip: When selecting artifacts to extract, prioritize trash 5-star artifacts—those with correct main stats but poor substats. Converting a +20 artifact with bad substats into 30 progress points (S4) clears inventory space and generates currency for a guaranteed viable piece. This is superior to using 3-star artifacts for XP.

Advanced Mechanics and Version Limitations

Be aware of version limitations to avoid missing crafts. The restriction of 1 craft per set per version means hoarding Elixirs without a plan is inefficient. Enter a new version with a clear target, such as a specific Crit Goblet for a main DPS or an Energy Recharge Circlet for a support.

Set versions (S1 through S5) impact cost. S2 sets often require 4 Elixirs for Sands and Circlets instead of the cheaper 2 or 3. Always verify the cost in the Transmuter interface before confirming.

Key Upcoming Dates:

• Version 6.0: September 10, 2025
• Version 6.3: January 14, 2026

These updates will likely introduce new artifact sets. Manage your Tablet of Tona offerings and Imaginarium Theater runs to coincide with these releases, ensuring a stockpile of Elixirs is ready for new best-in-slot gear.

FAQ

Is it worth using Sanctifying Elixir in Genshin Impact? Yes. Post-Version 5.5, the guaranteed substat upgrades at +20 make crafted artifacts highly reliable for filling specific gear gaps, particularly for difficult-to-acquire main stats like Crit Rate Goblets.

How do you get Sanctifying Elixir efficiently? The most efficient method is extracting unwanted +20 5-star artifacts (S4) for 30 Progress points each. You can also gather 6 Elixirs from Natlan Tribal Secret Spaces and earn them through the Battle Pass and Imaginarium Theater.

How many Sanctifying Elixirs do you need for one 5-star artifact? Costs vary by piece: Flower and Plume cost 1; Sands cost 2 (or 4 for S2); Goblets cost 4; and Circlets cost 3 (or 4 for S2).

Does the Artifact Strongbox guarantee good substats? The Strongbox allows you to select two substats, but the third and fourth are random. However, leveling the artifact to +20 guarantees two substat upgrades and locks them, ensuring a high-quality result.

What are the best artifact sets for Natlan characters? The Obsidian Codex set is a priority for 2026. Due to the high cost of Goblets (4 Elixirs), crafting these pieces for Natlan characters is often more resin-efficient than farming domains with bad RNG.

Can you craft relic sets in the Strongbox? Yes, the Artifact Transmuter supports crafting 5-star artifacts from various sets, including newer releases like Obsidian Codex, provided you have the Sanctifying Elixir and the specific set is available in the Transmuter rotation.